To date, almost all solid malignancies have implicated insulin-like growth factor (IGF) signalling as a driver of tumour growth.However, the remarkable level of crosstalk between sex hormones, the IGF-1 receptor (IGF-1R) and its ligands IGF-1 and 2 in endocrine driven cancers is incompletely understood.Similar to the sex steroids, IGF signalling is
In this paper we present a detailed single-pulse and polarization study of PSR J0614+2229 based on the archived data observed on 2019 August 15 (MJD 58710) and 2019 September 12 (MJD 58738) using the ultra−wide-bandwidth low-frequency receiver on the Parkes radio telescope.The single-pulse sequences show that this pulsar switches between two emis
AIM: To investigate the role of exosomal miR-29b and Ca2+ in regulating the function of human lens epithelial cells (HLECs).METHODS: Exosomes were isolated from human aqueous humour (AH) by ultracentrifugation, and visualized by nanoparticle tracking and transmission electron microscopy.Exosomal miRNA sequencing was performed to identify differenti
Thousands of vessels travel around the world every day, making the safety, efficiency, and optimization of marine transportation essential.Therefore, the knowledge of bathymetry is crucial for a variety of maritime applications, such as shipping and navigation.Maritime applications have benefited from recent advancements in satellite navigation tec
Abstract Background Osteoporosis is a complex multifactorial disease characterized by reduced bone mass and microarchitectural deterioration of bone tissue linked to an increase of fracture risk.Fragility fractures occur in osteoporotic subjects due to low-energy trauma.Osteoporotic patients are a challenge regarding the correct surgical planning,